The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2007
Filed:
Jun. 20, 2001
Applicants:
Henricus Petrus Joseph Te Riele, Amsterdam, NL;
Niels DE Wind, Leiderdorp, NL;
Helena Maria Johanna Dekker-vlaar, Obdam, NL;
Inventors:
Henricus Petrus Joseph Te Riele, Amsterdam, NL;
Niels De Wind, Leiderdorp, NL;
Helena Maria Johanna Dekker-Vlaar, Obdam, NL;
Assignee:
Mixis France S.A., Paris, FR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 15/00 (2006.01); A01K 67/00 (2006.01); A01K 67/027 (2006.01);
U.S. Cl.
CPC ...
Abstract
A mammalian cell having a mismatch repair-deficient phenotype is provided, where one or both alleles of a gene essential for mismatch repair, such as an Msh gene, are inactivated. Using this cell in a gene knock-out methodology advantageously allows efficient homologous recombination, even when the DNA sequences of the donor and recipient sequences diverge by significantly more than 0.6%.