The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2007
Filed:
Jul. 24, 2003
Carl Berthelette, Ste-Dorothee Laval, CA;
Nicholas Lachance, Montreal, CA;
Lianhai LI, Montreal, CA;
Claudio Sturino, L'ile-Bizard, CA;
Zhaoyin Wang, Kirkland, CA;
Robert N. Young, Senneville, CA;
Claude Dufresne, Dollard Des Ormeaux, CA;
Carl Berthelette, Ste-Dorothee Laval, CA;
Nicholas Lachance, Montreal, CA;
Lianhai Li, Montreal, CA;
Claudio Sturino, L'ile-Bizard, CA;
Zhaoyin Wang, Kirkland, CA;
Robert N. Young, Senneville, CA;
Claude Dufresne, Dollard Des Ormeaux, CA;
Merck Frosst Company, Kirkland, Quebec, CA;
Abstract
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events