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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7199128 B1

PDFFull Text
Expired
Date of Patent:
Apr. 03, 2007

Filed:

Feb. 01, 2006

8-n-substituted-2h-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents

Applicants:

Barton J. Bradbury, Wallingford, CT (US);

Jason Allan Wiles, Hamden, CT (US);

Milind Deshpande, Madison, CT (US);

Qiuping Wang, Bethany, CT (US);

Akihiro Hashimoto, Branford, CT (US);

Edlaine Lucien, New Haven, CT (US);

Inventors:

Barton J. Bradbury, Wallingford, CT (US);

Jason Allan Wiles, Hamden, CT (US);

Milind Deshpande, Madison, CT (US);

Qiuping Wang, Bethany, CT (US);

Akihiro Hashimoto, Branford, CT (US);

Edlaine Lucien, New Haven, CT (US);

Assignee:

Achillion Pharmaceuticals, Inc., New Haven, CT (US);

Attorney:

Cantor Colburn LLP

Primary Examiner:

Mark L Berch

Assistant Examiner:

Susanna Moore

Int. Cl.
CPC ...
A61K 31/429 (2006.01); A61K 31/424 (2006.01); C07D 498/14 (2006.01); C07D 498/20 (2006.01); C07D 513/14 (2006.01); C07D 513/20 (2006.01); A61P 31/04 (2006.01); C07D 455/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention provides compounds and salts of Formula I and Formula II: which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A, A, R, R, R, R, R, and Rare defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of compounds of Formula I and/or Formula II and one or more other active agents. The invention also provides methods for treating microbial and protozoal infections in animals.

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Bradbury, Barton. (2007). 8-n-substituted-2h-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents (U.S. Patent No. 7199128). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/7199128

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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