The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2007
Filed:
May. 16, 2001
Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby
Masami Miura, Tokyo, JP;
Masaaki Hirose, Tokyo, JP;
Taeko Miwa, Tokyo, JP;
Hiroyuki Irie, Tokyo, JP;
Shinobu Kuwae, Tokyo, JP;
Kenmi Miyano, Tokyo, JP;
Wataru Otani, Tokyo, JP;
Hideyuki Ohi, Tokyo, JP;
Masami Miura, Tokyo, JP;
Masaaki Hirose, Tokyo, JP;
Taeko Miwa, Tokyo, JP;
Hiroyuki Irie, Tokyo, JP;
Shinobu Kuwae, Tokyo, JP;
Kenmi Miyano, Tokyo, JP;
Wataru Otani, Tokyo, JP;
Hideyuki Ohi, Tokyo, JP;
Mitsubishi Pharma Corporation, Osaka, JP;
Abstract
The present invention intends to find out a gene participating in addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genusand provide a means of controlling the same. The present invention also intends to provide a process for producing a protein with reduction of an acidic sugar chain by using the thus controlled yeast strain belonging to the genus. Namely, the present invention includes a protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein; a gene encoding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belonging to the genushaving been transformed by this vector; a process for producing a protein with reduction of an acidic sugar chain by using the transformed yeast strain; and a glycoprotein thus produced.