The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 27, 2007

Filed:

Feb. 18, 2005
Applicants:

Michael G. Kelly, South San Francisco, CA (US);

Shimin Xu, Moorpark, CA (US);

Ning Xi, Thousand Oaks, CA (US);

Philip Miller, Headington, GB;

John F. Kincaid, San Diego, CA (US);

Chiara Ghiron, Wootton, GB;

Thomas Coulter, Wantage, GB;

Inventors:

Michael G. Kelly, South San Francisco, CA (US);

Shimin Xu, Moorpark, CA (US);

Ning Xi, Thousand Oaks, CA (US);

Philip Miller, Headington, GB;

John F. Kincaid, San Diego, CA (US);

Chiara Ghiron, Wootton, GB;

Thomas Coulter, Wantage, GB;

Assignee:

Amgen Inc., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); A61K 31/4427 (2006.01); C07D 401/02 (2006.01); C07D 421/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

The compounds of the invention are represented by the following general structure or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or inhibit PTH secretion, including methods for reducing or inhibiting PTH secretion and methods for treatment or prophylaxis of diseases associated with bone disorders, such as osteoporosis, or associated with excessive secretion of PTH, such as hyperparathyroidism. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.


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