The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2007
Filed:
Aug. 12, 2003
Min Gao, Madison, CT (US);
Julie A. Lemm, Durham, CT (US);
Donald R. O'boyle, Clinton, CT (US);
Peter Nower, Wethersfield, CT (US);
Karen Rigat, Clinton, CT (US);
Jin-hua Sun, North Haven, CT (US);
Min Gao, Madison, CT (US);
Julie A. Lemm, Durham, CT (US);
Donald R. O'Boyle, Clinton, CT (US);
Peter Nower, Wethersfield, CT (US);
Karen Rigat, Clinton, CT (US);
Jin-hua Sun, North Haven, CT (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention includes an assay useful for identifying inhibitors of Hepatitis C virus (HCV) activity. Particularly, the present invention is directed to a dual HCV assay useful for high throughput screening that quantifies both the amount of HCV RNA replication inhibitory activity associated with a test compound and the amount of cytotoxicity associated with that test compound. The present invention also includes compounds discovered using this assay, compositions containing such compounds and methods of treating Hepatitis C by the administration of such compounds. The present invention also includes reporter assays using enzymes associated with HCV RNA replication, as well as a cell line having ATTC Accession No. PTA-4583.