The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2007
Filed:
Feb. 24, 2004
Michael Barry Gravestock, Waltham, MA (US);
Daniel Robert Carcanague, Waltham, MA (US);
Neil James Hales, Macclesfield, GB;
Michael Barry Gravestock, Waltham, MA (US);
Daniel Robert Carcanague, Waltham, MA (US);
Neil James Hales, Macclesfield, GB;
AstraZeneca AB, Sodertajle, SE;
Abstract
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, (I) R1a is NH(C═W)Ror (a); W is O or S; Rand Rare for example H or F; Ris for example hydrogen, or halogen; Ris selected from hydrogen, (2–6C)alkyl (optionally substituted); Rand Rare independently selected from hydrogen, and (1–4C)alkyl (optionally substituted); wherein Ris either a hydroxymethyl substituent on C-4' of the isoxazoline ring; or Ris a hydroxymethyl substituent on C-5′ of the isoxazoline ring and the stereochemistry at C-5′ of the isoxazoline ring and at C-5 of the oxazolidinone ring is selected, such that the compound of formula (I) is a single diastereomer; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described