The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2007
Filed:
Mar. 28, 2005
Padam N. Sharma, Manlius, NY (US);
Edward J. Gublo, Liverpool, NY (US);
Gabriel M. Galvin, Maple Valley, WA (US);
Susan D. Boettger, Fayetteville, NY (US);
Saibaba Racha, Fayetteville, NY (US);
Padam N. Sharma, Manlius, NY (US);
Edward J. Gublo, Liverpool, NY (US);
Gabriel M. Galvin, Maple Valley, WA (US);
Susan D. Boettger, Fayetteville, NY (US);
Saibaba Racha, Fayetteville, NY (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
A process is provided for preparing a dipeptidyl peptidase IV inhibitor of the structure wherein is treated with TFAA in isopropyl acetate to protect the tertiary hydroxyl group as a trifluoroacetate group to form 4 (which is a novel intermediate)which is converted to acid chloride compound 5 (which is a novel compound)using Vilsmeier reagent or other chloro reagent and coupled with compound 6 in a heterogeneous mixture of ethyl acetate and aqueous bicarbonate to give compound 7 The N,O-bis(trifluoroacetyl) groups of compound 7 are deprotected to give free base compound 10.