Aminomethylpyrrolidine derivatives having aromatic substituents

Abstract

This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein Ris an optionally substituted aromatic group, a salt of the same or a hydrate of both. In the formula, R, R: hydrogen atom, an alkyl group; R, R, R: hydrogen atom, hydroxyl group, a halogen atom, carbamoyl group, an alkyl group, an alkoxyl group, an alkylthio group; R, R: hydrogen atom, an alkyl group; R: an alkyl group, an alkenyl group, a halogenoalkyl group, a cyclic alkyl group, an aryl group, a heteroaryl group, an alkoxyl group having from 1 to 6 carbon atoms, an alkylamino group; R:hydrogen atom, an alkylthio group; R: hydrogen atom, amino group, hydroxyl group, thiol group, a halogenomethyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; X: halogen atom, a hydrogen atom; A: nitrogen atom, C—X; X: hydrogen atom, amino group, a halogen atom, cyano group, an halogenomethyl group, a halogenomethoxyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxyl group; A, A:>C═C (—A═)—N(—R)—, >N—C (—A>)═C(—R)—; Rand Ror Rand Xmay be integrated to form a ring structure; and Y: hydrogen atom, ester forming group.