The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2007
Filed:
Mar. 04, 2002
Jean-claude Arnould, Reims, FR;
Jean-Claude Arnould, Reims, FR;
AstraZeneca AB, Sodertalje, SE;
Abstract
This invention relates to the use of compounds of Formula (I) as vascular damaging agents: wherein X is selected from: —O—, —S—, —S(O)—, —S(O)—, —N(R)—, —C(O)—, —C(O)N(R)—, —N(R)C(O)—, —S(O2)N(R)—, or —N(R)S(O)—; Ris independently selected from: amino, halo, hydroxy, —OPOH, Calkyl, or Calkoxy, wherein the amino group is optionally substituted by an amino acid residue and the hydroxy group is optionally esterified; Ris selected from: hydrogen or Calkyl; Ris selected from: hydrogen, halo, hydroxy, hydroxyCalkyl, cyano, cyanoCalkyl, carboxy, carboxyCalkyl, Calkanoyl, CalkanoylCalkyl, carbamoyl, carbamoylCalkyl, Calkoxy, Calkoxycarbonyl, CalkoxycarbonylCalkyl, Calkoxycarbonylamino, amino, N—Calkylamino, NN-diCalkylamino, aminoCalkyl, N—CalkylaminoCalkyl, NN-diCalkylaminoCalkyl, ureido, or Calkylureyleno; Ris independently selected from: Calkyl, Calkoxy or halo; Ris selected from: hydrogen or Calkyl; n is 0 or 1; p is 0, 1, 2 or 3; and q is 0, 1 or 2; or a salt, pro-drug or solvate thereof. The invention also relates to novel compounds of Formula (I) and to processes for the preparation of compounds of Formula (I).