The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2007
Filed:
Sep. 22, 2004
Bao-guo Huang, Bridgewater, NJ (US);
Witold Subotkowski, Whitehouse Station, NJ (US);
Duane Rudisill, Milford, NJ (US);
Bao-Guo Huang, Bridgewater, NJ (US);
Witold Subotkowski, Whitehouse Station, NJ (US);
Duane Rudisill, Milford, NJ (US);
Aventis Pharmaceuticals Inc., Bridgewater, NJ (US);
Abstract
The present invention relates to a process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives of the formula I, which are valuable pharmaceutical active ingredients and can be used, for example, as antidepressants. The process starts from O-ethyl phosphinates of the formula II into which, after silylation with hexamethyldisilazane, the 3-amino-2-hydroxypropyl moiety is introduced by reactions with epichlorohydrin and ammonia.