The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2007
Filed:
Apr. 03, 2002
Polynucleotides encoding novel cysteine proteases of the calpain superfamily, can-12v1 and can-12v2.
Jian Chen, Princeton, NJ (US);
Thomas C. Nelson, Lawrenceville, NJ (US);
Roy J. Vaz, North Branch, NJ (US);
Franck Duclos, Washington Crossing, PA (US);
Jian Chen, Princeton, NJ (US);
Thomas C. Nelson, Lawrenceville, NJ (US);
Roy J. Vaz, North Branch, NJ (US);
Franck Duclos, Washington Crossing, PA (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention provides novel polynucleotides encoding CAN-12 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of CAN-12 polypeptides, CAN-12v1 and CAN-12v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel CAN-12, CAN-12v1, and CAN-12v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly neuro- and musculo-degenerative conditions. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.