The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 27, 2007

Filed:

Apr. 19, 2005
Applicants:

Donald Eugene Butler, Holland, MI (US);

Randall Lee Dejong, Zeeland, MI (US);

Jade Douglas Nelson, Holland, MI (US);

Michael Gerard Pamment, Holland, MI (US);

Timothy Lee Stuk, Holland, MI (US);

Inventors:

Donald Eugene Butler, Holland, MI (US);

Randall Lee DeJong, Zeeland, MI (US);

Jade Douglas Nelson, Holland, MI (US);

Michael Gerard Pamment, Holland, MI (US);

Timothy Lee Stuk, Holland, MI (US);

Assignee:

Warner-Lambert Company, LLC, Morris Plains, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/06 (2006.01); C07D 401/06 (2006.01); C07D 406/06 (2006.01);
U.S. Cl.
CPC ...
Abstract

An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.


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