The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2007
Filed:
Aug. 14, 2003
Applicant:
Linda Jane Mccausland, West Lafayette, IN (US);
Inventor:
Linda Jane McCausland, West Lafayette, IN (US);
Assignee:
Accentus PLC, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Proteins may be made by genetically engineered microorganisms, the protein being stored in the form of inclusion bodies (IB). The proteins in the inclusion bodies are in an insoluble and inactive form. They may be dissolved using a solubilization reagent (), and the resulting solution diluted so that the proteins refold into the active form. This refolding of the protein is enhanced by subjecting a solution or suspension of the protein to low intensity sound waves (), at a low enough intensity that the protein is not denatured. The intensity may be between 10 and 100 mW/cm.