The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2007
Filed:
Jul. 25, 2001
Patrick Anthony Riley, London, GB;
Andrew Photiou, London, GB;
Tariq Hussain Khan, Bishop Stortford, Hertfordshire, GB;
Helen Mary Isted Osborn, Bishop Stortford, Hertfordshire, GB;
Hugh Malkin, Forest Hill, London, GB;
Patrick Anthony Riley, London, GB;
Andrew Photiou, London, GB;
Tariq Hussain Khan, Bishop Stortford, Hertfordshire, GB;
Helen Mary Isted Osborn, Bishop Stortford, Hertfordshire, GB;
Hugh Malkin, Forest Hill, London, GB;
Other;
Abstract
Novel mono- and dihydroxy phenylethylamine derivatives useful in treating melanoma are provided having the formulae (Ia, Ib or Ic). In the above formulae, Ris hydrogen or —COOR, Ris hydrogen or Calkyl; Rand Rindependently represent hydrogen and hydroxy, Ris hydrogen, C1–4? alkyl or halogen, X is —CHOH—, —CH-oxygen or sulphur, m is zero or 1, W is oxygen or sulphur, and —ODrug, —NHDrug and —N(Drug)each represent a residue of a therapeutically active agent. The above compounds are prodrugs which are inactive until metabolised by enzymes expressed by host melanoma cells. The invention allows a greater amount of active agent to be used while reducing systemic side effects