The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2007
Filed:
Oct. 29, 2002
Eddy Jean Edgard Freyne, 2340 Beerse, BE;
Peter Jacobus Johannes Antonius Buijnsters, 2340 Beese, BE;
Marc Willems, 2340 Beerse, BE;
Werner Constant Johan Embrechts, 2340 Beerse, BE;
Jean Fernand Armand Lacrampe, F-92787 Issy-les-Moulineaux, Cedex 9, FR;
Herwig Josephus Margareta Janssen, Legal Representative, 2970 Schilde, BE;
Paul Peter Maria Janssen, Legal Representative, 9052 Zwijnaarde, BE;
Graziella Maria Constantina Janssen, Legal Representative, 2300 Tumhout, BE;
Jasmine Josée Werner Janssen, Legal Representative, 2630 Aartselaar, BE;
Maroussia Godelieve Frank Janssen, Legal Representative, 1410 Waterloo, BE;
Theodora Joanna Francisca Arts, 2350 Vosselaar, BE;
Paulus Joannes Lewi, 2340 Beerse, BE;
Jan Heeres, 2340 Beerse, BE;
Marc René DE Jonge, 2340 Beerse, BE;
Lucien Maria Henricus Koymans, 2340 Beerse, BE;
Frederik Frans Desiré Daeyaert, 2340 Beerse, BE;
Michael Joseph Kukla, Maple Glen, PA (US);
Hugo Alfons Gabriel Geerts, Berwyn, PA (US);
Rony Maria Nuydens, 2340 Beerse, BE;
Marc Hubert Mercken, 2340 Beerse, BE;
Donald William Ludovici, Titusville, NJ (US);
Eddy Jean Edgard Freyne, 2340 Beerse, BE;
Peter Jacobus Johannes Antonius Buijnsters, 2340 Beese, BE;
Marc Willems, 2340 Beerse, BE;
Werner Constant Johan Embrechts, 2340 Beerse, BE;
Jean Fernand Armand Lacrampe, F-92787 Issy-les-Moulineaux, Cedex 9, FR;
Herwig Josephus Margareta Janssen, legal representative, 2970 Schilde, BE;
Paul Peter Maria Janssen, legal representative, 9052 Zwijnaarde, BE;
Graziella Maria Constantina Janssen, legal representative, 2300 Tumhout, BE;
Jasmine Josée Werner Janssen, legal representative, 2630 Aartselaar, BE;
Maroussia Godelieve Frank Janssen, legal representative, 1410 Waterloo, BE;
Theodora Joanna Francisca Arts, 2350 Vosselaar, BE;
Paulus Joannes Lewi, 2340 Beerse, BE;
Jan Heeres, 2340 Beerse, BE;
Marc René de Jonge, 2340 Beerse, BE;
Lucien Maria Henricus Koymans, 2340 Beerse, BE;
Frederik Frans Desiré Daeyaert, 2340 Beerse, BE;
Michael Joseph Kukla, Maple Glen, PA (US);
Hugo Alfons Gabriel Geerts, Berwyn, PA (US);
Rony Maria Nuydens, 2340 Beerse, BE;
Marc Hubert Mercken, 2340 Beerse, BE;
Donald William Ludovici, Titusville, NJ (US);
Other;
Abstract
This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents a 6-membered heterocycle; Ris hydrogen; aryl; formyl; Calkylcarbonyl; optionally substituted Calkyl; Calkyloxycarbonyl; optionally substituted CalkyloxyCalkylcarbonyl; X is a direct bond or a linker atom or group; Z is O or S; Ris hydrogen, Calkyl, Calkenyl, Calkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; Ris hydrogen; hydroxy; halo; optionally substituted Calkyl or Calkenyl or Calkynyl; Calkyloxy; Calkylthio; Calkyloxycarbonyl; Calkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(Calkyl)amino; polyhaloCalkyl; polyhaloCalkyloxy; polyhaloCalkylthio; R; R—Calkyl; R—O—; R—S—; R—C(═O)—; R—S(═O)—; R—S(═O)—; R—S(═O)—NH—; R—S(═O)—NH—; R—C(═O)—; —NHC(═O)H; —C(═O)NHNH; R—C(═O)—NH—; R—C(═O)—NH—; —C(═NH)R; —C(═NH)R; Ror Reach independently represent hydrogen, R, —Y—NR—Y—NRR, —Y—NR—Y—R, —Y—NRR; provided that —X—Rand/or Ris other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.