The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2007
Filed:
Jun. 10, 2004
Ernesto Freire, Baltimore, MD (US);
Patrick Ross, Baltimore, MD (US);
Yingxin Xiao, Gaithersburg, MD (US);
Raphael Ottenbrite, Midlothian, VA (US);
Irene Luque, Granada, ES;
Ernesto Freire, Baltimore, MD (US);
Patrick Ross, Baltimore, MD (US);
Yingxin Xiao, Gaithersburg, MD (US);
Raphael Ottenbrite, Midlothian, VA (US);
Irene Luque, Granada, ES;
The Johns Hopkins University, Baltimore, MD (US);
Fulcrum Pharmaceuticals Inc., Las Vagas, NV (US);
Abstract
The invention provides novel non-β-lactam inhibitors of β-lactamases. In particular, the invention provides boronic acid-based compounds set forth in the specification. These compounds may be used with β-lactam antibiotics to bacterial infection, particularly, β-lactam-antibiotic-resistant bacterial infections. These compounds are also antibacterial agents by themselves. The invention further provides methods of using such compounds. Finally, the invention provides a pharmaceutical composition comprising these compounds.