The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2007
Filed:
Dec. 31, 2003
Barbara Cordell, Palo Alto, CA (US);
Frauke Schimmöoller, Menlo Park, CA (US);
Yu-wang Liu, Santa Clara, CA (US);
Diana Hom Quon, Redwood City, CA (US);
Barbara Cordell, Palo Alto, CA (US);
Frauke Schimmöoller, Menlo Park, CA (US);
Yu-Wang Liu, Santa Clara, CA (US);
Diana Hom Quon, Redwood City, CA (US);
Scios Inc., Fremont, CA (US);
Abstract
The present invention is based on the findings that BACE2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of Aβ. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress Aβ production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases by reducing β-amyloid deposit formation.