The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2007
Filed:
Oct. 02, 2002
Gregory Biesecker, Boulder, CO (US);
Sumeda Jayasena, Boulder, CO (US);
Larry Gold, Boulder, CO (US);
Drew Smith, Boulder, CO (US);
Gary P. Kirschenheuter, Arvada, CO (US);
Gregory Biesecker, Boulder, CO (US);
Sumeda Jayasena, Boulder, CO (US);
Larry Gold, Boulder, CO (US);
Drew Smith, Boulder, CO (US);
Gary P. Kirschenheuter, Arvada, CO (US);
Gilead Sciences, Inc., Foster City, CA (US);
Abstract
A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated to the peptide Gly-Arg-Gly-Asp-Thr-Pro (SEQ ID NO:1). This blended RNA ligand inhibits the biological activity of gpIIbIIIa with high specificity. Also described is a single-stranded DNA ligand to elastase coupled to N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone (SEQ ID NO:2). This elastase blended nucleic acid ligand inhibits the biological activity of elastase.