The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2007
Filed:
Jan. 15, 2003
Tadashi Honda, Hanover, NH (US);
Frank G. Favaloro, Norfolk, MA (US);
Gordon W. Gribble, Lebanon, NH (US);
Michael B. Sporn, Tunbridge, VT (US);
Nanjoo Suh, White River Junction, VT (US);
Tadashi Honda, Hanover, NH (US);
Frank G. Favaloro, Norfolk, MA (US);
Gordon W. Gribble, Lebanon, NH (US);
Michael B. Sporn, Tunbridge, VT (US);
Nanjoo Suh, White River Junction, VT (US);
The Trustees of Dartmouth College, Hanover, NH (US);
Abstract
Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotropic lateral sclerosis, rheumatoid arthritis, inflammatory bowel disease, and all other diseases whose pathogenesis is believed to involve excessive production of either nitric oxide (NO) or prostaglandins or the overexpression of iNOS or COX-2 genes or gene products. Further, methods for the synthesis of the TBE compounds of the invention utilize cheap commercially available reagents and are highly cost effective and amenable to scale-up. Additional high efficiency synthetic methods that utilize novel intermediates as well as the synthesis of these intermediates are also provided. Furthermore, the invention also provides methods for designing novel and water-soluble TBEs.