The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2007
Filed:
Jul. 01, 2003
Sui Xiong Cai, San Diego, CA (US);
Shailaja Kasibhatla, San Diego, CA (US);
Kristin P. Ollis, San Diego, CA (US);
Han-zhong Zhang, San Diego, CA (US);
John A. Drewe, Carlsbad, CA (US);
Ben Tseng, San Diego, CA (US);
Nilantha Sudath Sirisoma, San Diego, CA (US);
Sui Xiong Cai, San Diego, CA (US);
Shailaja Kasibhatla, San Diego, CA (US);
Kristin P. Ollis, San Diego, CA (US);
Han-Zhong Zhang, San Diego, CA (US);
John A. Drewe, Carlsbad, CA (US);
Ben Tseng, San Diego, CA (US);
Nilantha Sudath Sirisoma, San Diego, CA (US);
Cytovia, Inc., San Diego, CA (US);
Abstract
The present invention is directed to derivatives of gambogic acid and analogs thereof. Exemplary gambogic acid derivatives of the present invention include, among others, derivatives substituted in the C10 and C28 positions of gambogic acid. The present invention also relates to the discovery that certain preferred compounds of the present invention are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.