The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2007
Filed:
Oct. 16, 2002
Jeremy Martin Davis, Workingham, GB;
Daniel Christopher Brookings, Reading, GB;
Barry John Langham, Reading, GB;
Jeremy Martin Davis, Workingham, GB;
Daniel Christopher Brookings, Reading, GB;
Barry John Langham, Reading, GB;
Celltech R&D Limited, Berkshire, GB;
Abstract
Compounds of formulae (1a) and (1b) are described: in which the dashed line represents an optional bond; A is a —N═ atom or a —N(R)—, —C(R)═ or —C(R)(R)— group; R, Rand Ris each independently a hydrogen atom or an optionally substituted Calkyl group; X is an —O— or —S— atom or —NH— group or substituted N atom; each Y is independently a N atom or CH group or substituted C atom; n is zero or the integer 1; Alkis an optionally substituted aliphatic or heteroaliphatic chain Lis a covalent bond or a linker atom or group; Cyis a hydrogen atom or an optionally substituted cycloaliphatic, polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group; Ar is an optionally substituted aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof; The compounds are potent inhibitors of p38 kinase and are use in the prophylaxis or treatment of p38 kinase mediated diseases or disorders, such as rheumatoid arthritis