The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2007
Filed:
Feb. 04, 2004
Gloria Anne Breault, Macclesfield, GB;
Janet Elizabeth Pease, Macclesfiled, GB;
Gloria Anne Breault, Macclesfield, GB;
Janet Elizabeth Pease, Macclesfiled, GB;
AstraZeneca AB, Sodertalje, SE;
Abstract
A pyrimidine derivative of formula (I) wherein, for example, Ris hydrogen, (1–6C)alkyl, (3–5C)alkenyl or (3–5C)alkynyl; Qand Qare independently selected from phenyl, naphthyl, indanyl and 1,2,3,4-tetrahydronaphthyl; and one or both of Qand Qbears on any available carbon atom one substituent of formula (Ia) [provided that when present in Qthe substituent of formula (Ia) is not adjacent to the —NH— link]; wherein, for example, X is CH, O, S or NH; Y is H or as defined for Z; Z is OH, SH, NH, (1–4C)alkoxy, (1–4C)alkylthio, —NH(1–C)alkyl, —N[(1–4C)alkyl]or —NH—(3–8C)cycloalkyl; n is 1, 2 or 3; m is 1, 2 or 3; and Qand Qmay optionally bear other substituents selected, for example, from halogeno, (1–6C)alkyl, cyano and (2–4C)alkenyl; or a pharmaceutically-acceptable salt or in-vivo-hydrolyzable ester thereof; are useful as anti-cancer agents; and processes for heir manufacture and pharmaceutical compositions containing them are described