The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2007
Filed:
Dec. 16, 2002
Jerry M. Collins, Rockville, MD (US);
Raymond W. Klecker, Jr., Silver Spring, MD (US);
Lawrence W. Anderson, Wheaton, MD (US);
Jerry M. Collins, Rockville, MD (US);
Raymond W. Klecker, Jr., Silver Spring, MD (US);
Lawrence W. Anderson, Wheaton, MD (US);
Abstract
The use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labeled anticancer drug to a patient and imaging at least a part of the patient using Positron Emission Tomography imaging is described. The method can be used to monitor delivery of antitumor drugs to tumors, to predict the effectiveness of therapy with a particular antitumor drug or combination of antitumor drugs, to assess the effectiveness of modulators of cellular accumulation, to individualize therapy and to evaluate the effectiveness of antitumor drugs with respect to particular cancers. Particularly preferred drugs are labeled taxanes, e.g.,C-paclitaxel andC-docetaxel, labeled anthracyclines, e.g.,C-doxorubicin andC-epirubicin, and other radiolabeled drugs, e.g.C-topotecan,C-SN-38, andC-imatinib. The invention further describes antitumor drugs labeled with the radioactive labelC and methods of preparing radio-labeled drugs.