The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2007
Filed:
Dec. 09, 2003
Kyriacos C. Nicolaou, La Jolla, CA (US);
Yun He, San Diego, CA (US);
Sacha Ninkovic, Carlsbad, CA (US);
Joaquin Pastor, Cobisa, ES;
Frank Roschangar, Glen Allen, VA (US);
Francisco Sarabia, Torre de Benagalbon, ES;
Hans Vallberg, Huddinge, SE;
Dionisios Vourloumis, San Diego, CA (US);
Nicolas Winssinger, Strasbourg, FR;
Zhen Yang, Boston, MA (US);
Nigel Paul King, Hitchen, GB;
Maurice Raymond Verschoyle Finlay, Macclesfield, GB;
Kyriacos C. Nicolaou, La Jolla, CA (US);
Yun He, San Diego, CA (US);
Sacha Ninkovic, Carlsbad, CA (US);
Joaquin Pastor, Cobisa, ES;
Frank Roschangar, Glen Allen, VA (US);
Francisco Sarabia, Torre de Benagalbon, ES;
Hans Vallberg, Huddinge, SE;
Dionisios Vourloumis, San Diego, CA (US);
Nicolas Winssinger, Strasbourg, FR;
Zhen Yang, Boston, MA (US);
Nigel Paul King, Hitchen, GB;
Maurice Raymond Verschoyle Finlay, Macclesfield, GB;
The Scripps Research Institute, La Jolla, CA (US);
Abstract
Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancers agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of epothilone are novel. Several of the analogs are demonstrated to have a superior cytotoxic activity as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules.