The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2007
Filed:
Dec. 12, 2003
Stephen M. Strittmatter, Clinton, CT (US);
Richard L. Cate, Cohasset, MA (US);
Dinah W. Y. Sah, Boston, MA (US);
Stephen M. Strittmatter, Clinton, CT (US);
Richard L. Cate, Cohasset, MA (US);
Dinah W. Y. Sah, Boston, MA (US);
Biogen Idec MA Inc., Cambridge, MA (US);
Yale University, New Haven, CT (US);
Abstract
The invention relates generally to genes that encode proteins that inhibit axonal growth. The invention relates specifically to genes encoding NgR protein homologs in humans and mice. The invention also includes compositions and methods for modulating the expression and activity of Nogo and the NgR proteins. Specifically, the invention includes peptides, proteins and antibodies that block Nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in the treatment of cranial or cerebral trauma, spinal cord injury, stroke or a demyelinating disease.