The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2007
Filed:
Feb. 28, 2003
Zhongli Zheng, Lexington, MA (US);
Mary-beth Carter, Arlington, MA (US);
Yusheng Liao, Lexington, MA (US);
Lihong Sun, Arlington, MA (US);
Leonid Kirkovsky, San Diego, CA (US);
Susan Mrose, Brookline, MA (US);
Yen-ming Hsu, Lexington, MA (US);
David Thomas, Houston, TX (US);
Gerald W. Shipps, Jr., Stoneham, MA (US);
Satish Jindal, Milton, MA (US);
George R. Lenz, Andover, MA (US);
Huw M. Nash, Cambridge, MA (US);
Zhongli Zheng, Lexington, MA (US);
Mary-Beth Carter, Arlington, MA (US);
YuSheng Liao, Lexington, MA (US);
Lihong Sun, Arlington, MA (US);
Leonid Kirkovsky, San Diego, CA (US);
Susan Mrose, Brookline, MA (US);
Yen-Ming Hsu, Lexington, MA (US);
David Thomas, Houston, TX (US);
Gerald W. Shipps, Jr., Stoneham, MA (US);
Satish Jindal, Milton, MA (US);
George R. Lenz, Andover, MA (US);
Huw M. Nash, Cambridge, MA (US);
Biogen, Inc., Cambridge, MA (US);
Abstract
The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention provides compounds which are identified by screening a library of small molecules for those that are capable of specifically binding CD154 and interrupting CD40:CD154 interaction.