The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2007
Filed:
Jan. 15, 2003
Hongyue Dai, Bothell, WA (US);
Yudong He, Kirkland, WA (US);
Peter S. Linsley, Seattle, WA (US);
Mao Mao, Kirkland, WA (US);
Christopher J. Roberts, Seattle, WA (US);
Laura Johanna Van't Veer, Amsterdam, NL;
Marc J. Van DE Vijver, Amsterdam, NL;
Rene Bernards, Abcoude, NL;
A. A. M. Hart, Castricum, NL;
Hongyue Dai, Bothell, WA (US);
Yudong He, Kirkland, WA (US);
Peter S. Linsley, Seattle, WA (US);
Mao Mao, Kirkland, WA (US);
Christopher J. Roberts, Seattle, WA (US);
Laura Johanna Van't Veer, Amsterdam, NL;
Marc J. Van de Vijver, Amsterdam, NL;
Rene Bernards, Abcoude, NL;
A. A. M. Hart, Castricum, NL;
Rosetta Inpharmatics LLC, Seattle, WA (US);
Netherlands Cancer Institute, Amsterdam, NL;
Abstract
The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also provides methods of classifying and treating patients based on prognosis. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the diagnostic, prognostic and statistical methods disclosed herein.