The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2007
Filed:
Feb. 26, 2003
Romeo Ciabatti, Novate Milanese, IT;
Sonia Maffioli, Milan, IT;
Anna Checchia, Bovisio Masciago, IT;
Gabriella Romano, Legnano, IT;
Gianpaolo Candiani, Gorgonzola, IT;
Gianbattista Panzone, Cornaredo, IT;
Romeo Ciabatti, Novate Milanese, IT;
Sonia Maffioli, Milan, IT;
Anna Checchia, Bovisio Masciago, IT;
Gabriella Romano, Legnano, IT;
Gianpaolo Candiani, Gorgonzola, IT;
Gianbattista Panzone, Cornaredo, IT;
Vicuron Pharmaceuticals Inc., King of Prussia, PA (US);
Abstract
The invention regards a process for the production of ramoplanin-like derivatives of formula (I): RAMO-NC—CO—R (I), wherein the radical R represents a hydrocarbon radical and the portion RAMO-NH— represents deacylated ramoplanin, any of its factors or ramoplanose. The compound of Formula (I) are obtained by reacting a carboxylic acid R—COOH with deacylated ramoplanin, any of its factors or ramoplanose protected on the ornitine amino groups. New compounds wherein the hydrocarbon radical R is different form those characaterizing the ramoplanin and ramoplanose natural products and their tetrahydro-derivatives are calimed. The new compounds have the same or better antinfective activity, lower haemolytic effect and better tolerability profile than ramoplanin.