The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 23, 2007

Filed:

May. 05, 2004
Applicants:

Linda G. Lee, Palo Alto, CA (US);

Ronald J. Graham, San Ramon, CA (US);

Khairuzzaman B. Mullah, Union City, CA (US);

Francis T. Haxo, San Francisco, CA (US);

Inventors:

Linda G. Lee, Palo Alto, CA (US);

Ronald J. Graham, San Ramon, CA (US);

Khairuzzaman B. Mullah, Union City, CA (US);

Francis T. Haxo, San Francisco, CA (US);

Assignee:

Applera Corporation, Foster City, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 19/04 (2006.01); C07D 293/00 (2006.01); C07D 421/00 (2006.01); C07D 293/10 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention provides an asymmetric cyanine dye compound having the structure including substituted forms thereof, wherein, at least one of Rand Ris linking group, X is O, S, or Se, and n ranges from 0 to 2. The invention further provides reporter-quencher dye pairs comprising the asymmetric cyanine dyes, dye-labelled polynucleotides incorporating the asymmetric cyanine dyes, and hybridization detection methods utilizing the dye-labelled polynucleotides.


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