The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2007
Filed:
Sep. 02, 2004
Alexander Krantz, San Francisco, CA (US);
Wolin Huang, Foster City, CA (US);
Arthur M. Hanel, San Francisco, CA (US);
Darren L. Holmes, Montreal, CA;
Dominique P. Bridon, Ville Mont-Royal, CA;
Alexander Krantz, San Francisco, CA (US);
Wolin Huang, Foster City, CA (US);
Arthur M. Hanel, San Francisco, CA (US);
Darren L. Holmes, Montreal, CA;
Dominique P. Bridon, Ville Mont-Royal, CA;
ConjuChem Biotechnologies Inc., Montreal, CA;
Abstract
Methods and compositions are provided for identifying compounds having affinity or complementarity to a target molecule. Compounds according to the invention may be described by the formula E-C—R—C-A, wherein E is a therapeutic or diagnostic agent, R is a reactive group, Cand Care connector groups between E and R and between R and A, respectively, and A is an affinity group comprising the sequence F--Y-E-E. Compounds according to the invention may be used for labeling the target molecule, particularly where the target molecule is naturally found in a complex mixture, such as a physiological fluid, like blood. By affinity labeling in vivo, the lifetime of physiologically active entities can be greatly enhanced by becoming bound to long-lived blood components. The covalently bound entity may also serve as an antagonist or agonist of a particular binding protein or as an enzyme inhibitor.