The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2007
Filed:
Oct. 09, 2002
Clive Leslie Branch, Harlow, GB;
Christopher Norbert Johnson, Harlow, GB;
David John Nash, Harlow, GB;
Geoffrey Stemp, Harlow, GB;
Clive Leslie Branch, Harlow, GB;
Christopher Norbert Johnson, Harlow, GB;
David John Nash, Harlow, GB;
Geoffrey Stemp, Harlow, GB;
SmithKline Beecham p.l.c., Brentford, GB;
Abstract
This invention relates to N-aroyl piperazine derivatives of formula (I), wherein: Y represents NR; m represents 1, 2 or 3; p represents 0 or 1; X is O, S, C═O, SO, or CH═CH—; Aris aryl, or a mono or bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; any of which may be optionally substituted; Arrepresents phenyl or a 5- or 6-membered heterocyclyl group containing 1 to 3 heteroatoms selected from N, O and S, wherein the phenyl heterocyclyl group is substituted by Rand further optional substituents; or Arrepresents an optionally substituted bicyclic aromatic or bicyclic heteroaromatic group containing 1 to 4 heteroatoms selected from N, O and S; Rrepresents optionally substituted (C)alkoxy, halo, optionally substituted (C)alkyl, optionally substituted phenyl, or an optionally substituted 5- or 6-membered heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S; Rrepresents hydrogen, optionally substituted (C)alkyl, optionally substituted (C)alkanoyl, optionally subtituted (C)alkanoxycarbonyl or optionally substituted aryl(C)alkyloxycarbonyl; and their use as orexin receptor-antagonists.