The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2007
Filed:
Nov. 01, 2000
Alan D. Attie, Madison, WI (US);
Mark Cook, Madison, WI (US);
Mark P. Gray-keller, Middleton, WI (US);
Michael R. Hayden, Vancouver, CA;
Simon Pimstone, Vancouver, CA;
Angela R. Brooks-wilson, Vancouver, CA;
Alan D. Attie, Madison, WI (US);
Mark Cook, Madison, WI (US);
Mark P. Gray-Keller, Middleton, WI (US);
Michael R. Hayden, Vancouver, CA;
Simon Pimstone, Vancouver, CA;
Angela R. Brooks-Wilson, Vancouver, CA;
Wisconsin Alumni Research Foundation, Madison, WI (US);
Xenon Genetics, Inc., Burnaby, CA;
Abstract
Methods and compounds are disclosed for lowering serum LDL levels or serum cholesterol levels, or for reducing the transport of cholesterol from the gut to the blood or the lymph, based on the observation that a gene known as ABC1 is necessary in order for cholesterol to be transported from the intestinal lumen into the bloodstream. A mutant chicken phenotype, known as the WHAM chicken, characterized by low levels of serum LDL and reduced transport of cholesterol, facilitated the discovery of this function of the ABC1 gene. Techniques which act to inhibit ABC1 activity in the cells of the intestinal wall will result in lower serum cholesterol.