The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 2007
Filed:
Jul. 03, 2003
Richard A. Earl, Westford, MA (US);
Maiko Ezawa, Acton, MA (US);
Xinqin Fang, Lexington, MA (US);
David S. Garvey, Dover, MA (US);
Ricky D. Gaston, Malden, MA (US);
Subhash P. Khanapure, Clinton, MA (US);
L. Gordon Letts, Dover, MA (US);
Chia-en Lin, Burlington, MA (US);
Ramani R. Ranatunge, Lexington, MA (US);
Stewart K. Richardson, Tolland, CT (US);
Joseph D. Schroeder, Minneapolis, MN (US);
Cheri A. Stevenson, Haverhill, MA (US);
Shiow-jyi Wey, Woburn, MA (US);
Richard A. Earl, Westford, MA (US);
Maiko Ezawa, Acton, MA (US);
Xinqin Fang, Lexington, MA (US);
David S. Garvey, Dover, MA (US);
Ricky D. Gaston, Malden, MA (US);
Subhash P. Khanapure, Clinton, MA (US);
L. Gordon Letts, Dover, MA (US);
Chia-En Lin, Burlington, MA (US);
Ramani R. Ranatunge, Lexington, MA (US);
Stewart K. Richardson, Tolland, CT (US);
Joseph D. Schroeder, Minneapolis, MN (US);
Cheri A. Stevenson, Haverhill, MA (US);
Shiow-Jyi Wey, Woburn, MA (US);
NitroMed Inc., Lexington, MA (US);
Abstract
The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.