Azole compound and medicinal use thereof

Abstract

The present invention relates to an azole compound represented by the formula [I] wherein W is S or O; R is —COOR, —X-A-COOR(Ris H, alkyl) or tetrazolyl; R, R, Rand Rare H and the like; A is —(CH)—X— (X is —N(R)—, —C(R)(R)—, —CO— or —CO—N(R)—); B is aryl or aromatic heterocyclic group; Ris H and the like; Ris —(Y)-(A)-Z (Y is —O—, —S(O)—, —N(R)—, —N(R)—CO—, —N(R)—SO—, —SO—N(R)— and the like, Ais alkylene, and Z is cycloalkyl, aryl, aromatic heterocyclic group, indanyl, piperazinyl, a prodrug thereof or a pharmaceutically acceptable salt thereof. The compound [I] of the present invention has a protein tyrosine phosphatase 1B inhibitory activity, and is useful as a therapeutic agent for diabetes, a therapeutic drug for diabetic complications or a therapeutic drug for hyperlipidemia.