The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 16, 2007
Filed:
Oct. 15, 2002
David Knaack, Holmdel, NJ (US);
Kathy Traianedes, North Brunswick, NJ (US);
Michele Diegman, Scotch Plains, NJ (US);
Nanette Forsyth, Bayville, NJ (US);
John Winterbottom, Jackson, NJ (US);
David Knaack, Holmdel, NJ (US);
Kathy Traianedes, North Brunswick, NJ (US);
Michele Diegman, Scotch Plains, NJ (US);
Nanette Forsyth, Bayville, NJ (US);
John Winterbottom, Jackson, NJ (US);
Osteotech, Inc., Eatontown, NJ (US);
Abstract
An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-β, BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions.