The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 09, 2007
Filed:
Jan. 19, 2006
Hassan Mahmoud Elokdah, Yardley, PA (US);
Geraldine Ruth Mcfarlane, Monmouth Junction, NJ (US);
David Zenan LI, Princeton, NJ (US);
Hassan Mahmoud Elokdah, Yardley, PA (US);
Geraldine Ruth McFarlane, Monmouth Junction, NJ (US);
David Zenan Li, Princeton, NJ (US);
Other;
Abstract
This invention provides indole oxo-acetyl amino acetic acid derivatives which are useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) useful for treating fibrinolytic disorders, the compounds having the structure: wherein: Ris alkyl or optionally substituted cycloalkyl, —CH-cycloalkyl, pyridinyl, —CH-pyridinyl, phenyl or benzyl; Ris hydrogen, alkyl, cycloalkyl, —CH-cycloalkyl, or perfluoroalkyl; Ris hydrogen, halo, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, —CH-cycloalkyl, —NH, or —NO; Ris optionally substituted phenyl, benzyl, benzyloxy, pyridinyl, or —CH-pyridinyl; Ris hydrogen, alkyl, cycloalkyl, —CH-cycloalkyl, perfluoroalkyl, aryl, substituted aryl, alkyl-aryl, or substituted alkyl-aryl; Ris hydrogen, alkyl, hydroxyalkyl, 4-hydroxybenzyl, 3-indolylymethylene, 4-imidazolylmethylene, HSCH—, CHSCHCH—, HNC(═O)CH—, HNC(═O)CHCH—, HOCCH—, HOCCHCH—, HNCHCHCHCH—, HNC(═NH)NHCHCHCH—, or taken together with Ras —CHCHCH—; or a pharmaceutically acceptable salt or ester form thereof.