The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 09, 2007

Filed:

Jan. 27, 2004
Applicants:

Torsten Hoffmann, Weil am Rhein, DE;

Fabienne Hoffmann-emery, Weil am Rhein, DE;

Sonja Nick, Basel, CH;

Urs Schwitter, Reinach, CH;

Pius Waldmeier, Wegenstetten, CH;

Inventors:

Torsten Hoffmann, Weil am Rhein, DE;

Fabienne Hoffmann-Emery, Weil am Rhein, DE;

Sonja Nick, Basel, CH;

Urs Schwitter, Reinach, CH;

Pius Waldmeier, Wegenstetten, CH;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 279/10 (2006.01); C07D 279/12 (2006.01); C07D 295/00 (2006.01); A61K 31/54 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to a new crystalline modification of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-(1,1-dioxo-1λ-thiomorpholin-4-yl)-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide characterized by the following X-ray diffraction pattern obtained with a Cu, radiation at 2θ (2Theta)=4.5, 6.4, 7.5, 7.7, 8.0, 8.2, 10.0, 10.2, 10.9, 11.1, 12.9, 13.4, 14.0, 14.5, 15.1, 15.6, 16.2, 16.5, 17.3, 17.5, 18.0, 18.9, 19.3, 19.5, 19.9, 20.1, 20.6, 21.0, 21.4, 22.7, 23.1 and 23.6 and an infrared spectrum having sharp bands at 2925, 2854, 1637, 1604, 1484, 1395, 1375, 1285, 1230, 1172, 1125, 1082, 999, 943, 893, 868, 860, 782, 705, 684 cm, and wherein the extrapolated melting point (DSC) is 137.2° C.


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