The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 09, 2007

Filed:

May. 13, 2004
Applicants:

Mark Abel, Edmonton, CA;

Roman Szweda, Edmonton, CA;

Daniel Trepanier, Edmonton, CA;

Randall W Yatscoff, Edmonton, CA;

Robert T. Foster, Edmonton, CA;

Inventors:

Mark Abel, Edmonton, CA;

Roman Szweda, Edmonton, CA;

Daniel Trepanier, Edmonton, CA;

Randall W Yatscoff, Edmonton, CA;

Robert T. Foster, Edmonton, CA;

Assignee:

Isotechnika, Inc., Edmonton, CA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); A61K 31/44 (2006.01); C07H 15/00 (2006.01); C07D 487/00 (2006.01); A61F 13/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin carbohydrate derivatives having enhanced pharmacokinetic and/or pharmacodynamic profiles. For example, administration of the rapamycin carbohydrate derivative results in altered pharmacokinetic profiles and reduced toxicities. Thus, the present invention provides compounds with characteristics that are distinct from other drugs in its class such as rapamycin.


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