The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2007
Filed:
Feb. 10, 2000
Steven Pirie-shepherd, Waltham, MA (US);
M. Judah Folkman, Brookline, MA (US);
Kim Lee Sim, Gaithersburg, MD (US);
Nicholas Macdonald, Chevy Chase, MD (US);
Hong Liang, Gaithersburg, MD (US);
Steven Pirie-Shepherd, Waltham, MA (US);
M. Judah Folkman, Brookline, MA (US);
Kim Lee Sim, Gaithersburg, MD (US);
Nicholas MacDonald, Chevy Chase, MD (US);
Hong LiAng, Gaithersburg, MD (US);
The Children's Medical Center Corporation, Boston, MA (US);
Abstract
Disclosed are deglycosylated fragments of a kringle 1-3 region of plasminogen, nucleotides encoding deglycosylated kringle 1-3 region proteins and antibodies specific for deglycosylated kringle 1-3 region proteins. The compositions of the present invention have increased antiangiogenic activity as compared to previously isolated kringle 1-3 region proteins. Also included in the present invention are methods of treating angiogenesis-associated diseases and conditions such as cancer using the compositions described herein.