The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2007
Filed:
Feb. 02, 2004
David Joseph Bartkovitz, Nutley, NJ (US);
Xin-jie Chu, Livingston, NJ (US);
Qingjie Ding, Bridgewater, NJ (US);
Nan Jiang, Fairfield, NJ (US);
Allen John Lovey, North Caldwell, NJ (US);
John Anthony Moliterni, Staten Island, NY (US);
John Guilfoyle Mullin, Jr., Hawthorne, NJ (US);
Binh Thanh VU, North Caldwell, NJ (US);
Peter Michael Wovkulich, Nutley, NJ (US);
David Joseph Bartkovitz, Nutley, NJ (US);
Xin-Jie Chu, Livingston, NJ (US);
Qingjie Ding, Bridgewater, NJ (US);
Nan Jiang, Fairfield, NJ (US);
Allen John Lovey, North Caldwell, NJ (US);
John Anthony Moliterni, Staten Island, NY (US);
John Guilfoyle Mullin, Jr., Hawthorne, NJ (US);
Binh Thanh Vu, North Caldwell, NJ (US);
Peter Michael Wovkulich, Nutley, NJ (US);
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
Novel 4-aminopyrimidine-5-one derivatives are disclosed. These compounds inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminopyrimidine-5-one derivatives.