The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 2007
Filed:
Apr. 21, 1998
Robert J. Obremski, Yorba Linda, CA (US);
John W. Silzel, Yorba Linda, CA (US);
Tsong-tseh Tsay, Orange, CA (US);
Bibijana Cercek, Yorba Linda, CA (US);
Charles L. Dodson, Orange, CA (US);
Tung Rung Wang, Fullerton, CA (US);
Yagang Liu, Irvine, CA (US);
Zhou Shaomin, Yorba Linda, CA (US);
Robert J. Obremski, Yorba Linda, CA (US);
John W. Silzel, Yorba Linda, CA (US);
Tsong-Tseh Tsay, Orange, CA (US);
Bibijana Cercek, Yorba Linda, CA (US);
Charles L. Dodson, Orange, CA (US);
Tung Rung Wang, Fullerton, CA (US);
Yagang Liu, Irvine, CA (US);
Zhou Shaomin, Yorba Linda, CA (US);
Beckman Coulter, Inc., Fullerton, CA (US);
Abstract
A microscale binding assay, analyte binding array, and kits are disclosed, which exploit the mass action law to harvest analyte from a liquid sample. This is achieved by fabrication of sorbent zones having up to ten times the binding capacity per unit area generally obtained on polystyrene microtiter plates. The resulting arrays substantially deplete the liquid solution of analyte during incubation. Accordingly, the assays respond to total mass of analyte in the sample, not analyte concentration. This approach, coupled with direct fluorescence detection in the NIR, yields maximal signal intensity and low background for optimal sensitivity.