The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2006
Filed:
Sep. 07, 2005
Applicants:
Paul O'shea, Westmont, CA;
Francis Gosselin, Montreal, CA;
Inventors:
Paul O'Shea, Westmont, CA;
Francis Gosselin, Montreal, CA;
Assignee:
Merck Frosst Canada, Ltd., Kirkland, CA;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 209/66 (2006.01);
U.S. Cl.
CPC ...
Abstract
This invention describes the reaction of an alpha fluoroalkyl ketone with a bis(trialkylsilyl)amide to give a stable N-trialkylsilyl imine. Treatment of the N-trialkylsilyl imine with an alcohol leads to solvolysis of the trialkylsilyl group and yields a stable mixture of an aminal and an imine in high yield. Catalytic reduction of this mixture, or of the individual components, in the presence of a chiral catalyst leads to a fluoroalkyl amine with high enantioselectivity and high yield.