The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2006
Filed:
Jul. 12, 2002
Applicants:
Troels Koch, Copenhagen, DK;
Christoph Rosenbohn, Copenhagen, DK;
Daniel Sejer Pedersen, Copenhagen, DK;
Inventors:
Troels Koch, Copenhagen, DK;
Christoph Rosenbohn, Copenhagen, DK;
Daniel Sejer Pedersen, Copenhagen, DK;
Assignee:
Santaris Pharma A/S, Horsholm, DK;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to large scale preparation of LNA phosphoramidites using a 2-cyanoethyl-N,N,N',N′-tetra-substituted phosphoramidite and a nucleophilic activator, e.g. 2-cyanoethyl-N,N,N′,N′-tetraisopropylphosphoramidite and 4,5-dicyanoimidazole. The method is faster and more cost efficient that previously known methods.