The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2006
Filed:
Mar. 13, 2003
Lawrence W. Stanton, Singapore, SG;
Ralph Brandenberger, Menlo Park, CA (US);
Joseph D. Gold, San Francisco, CA (US);
John M. Irving, San Mateo, CA (US);
Ramkumar Mandalam, Union City, CA (US);
Michael Mok, Palo Alto, CA (US);
Lawrence W. Stanton, Singapore, SG;
Ralph Brandenberger, Menlo Park, CA (US);
Joseph D. Gold, San Francisco, CA (US);
John M. Irving, San Mateo, CA (US);
Ramkumar Mandalam, Union City, CA (US);
Michael Mok, Palo Alto, CA (US);
Geron Corporation, Menlo Park, CA (US);
Abstract
This disclosure provides a system for qualifying embryonic stem cells intended for human therapy. A large-scale sequencing project has identified important markers that are characteristic of undifferentiated pluripotent cells. Combinations of these markers can be used to validate the self-renewing capacity of ES cells, and their ability to differentiate into tissue types suitable for regenerative medicine. The marker system of this invention has been used to screen feeder cells, media additives, and culture conditions that promote proliferation of stem cells without differentiation. A culture system optimized by following these markers is suitable for rapid expansion of undifferentiated cells from existing lines, or the derivation of new lines that are equally apposite for clinical use.