The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2006
Filed:
Jan. 10, 2002
Applicant:
James A. Shayman, Ann Arbor, MI (US);
Inventor:
James A. Shayman, Ann Arbor, MI (US);
Assignee:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/396 (2006.01); A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/4453 (2006.01); A61K 31/5375 (2006.01); C07D 207/04 (2006.01); C07D 211/06 (2006.01); C07D 265/30 (2006.01); C07D 205/04 (2006.01); C07D 203/06 (2006.01);
U.S. Cl.
CPC ...
Abstract
Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.