The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 12, 2006

Filed:

Jul. 29, 2002
Applicants:

Peter Charles Astles, Basingstoke, GB;

Stephen Richard Baker, Basingstoke, GB;

Rowena Villanueva Cube, San Diego, CA (US);

Jose Antonio Martinez-perez, Alcoberidas-Madrid, ES;

Ana Isabel Mateo Herranz, Alcobendas-Madrid, ES;

Jean Michel Vernier, San Diego, CA (US);

Colin Peter Dell, Basingstoke, GB;

Sonia Gutierrez, Alcobendas-Madrid, ES;

Lourdes Prieto, Alcobendas-Madrid, ES;

Martine Keenan, Basingstoke, GB;

Adam Jan Sanderson, Basingstoke, GB;

Colin William Smith, Basingstoke, GB;

Inventors:

Peter Charles Astles, Basingstoke, GB;

Stephen Richard Baker, Basingstoke, GB;

Rowena Villanueva Cube, San Diego, CA (US);

Jose Antonio Martinez-Perez, Alcoberidas-Madrid, ES;

Ana Isabel Mateo Herranz, Alcobendas-Madrid, ES;

Jean Michel Vernier, San Diego, CA (US);

Colin Peter Dell, Basingstoke, GB;

Sonia Gutierrez, Alcobendas-Madrid, ES;

Lourdes Prieto, Alcobendas-Madrid, ES;

Martine Keenan, Basingstoke, GB;

Adam Jan Sanderson, Basingstoke, GB;

Colin William Smith, Basingstoke, GB;

Assignee:

Merck & Co., Inc., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 43/42 (2006.01); A61K 31/44 (2006.01); C07D 451/02 (2006.01); C07D 451/04 (2006.01); C07D 451/06 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to compounds that modulate neurotransmission by promoting the release of neurotransmitters such as acetylcholine, dopamine and norepinephrine. More particularly, the present invention relates to thio-bridged aryl compounds that are capable of modulating acetylcholine receptors and pharmaceutical compositions comprising such compounds. The compounds disclosed are useful for the treatment of dysfunctions of the central and autonomic nervous systems.


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