The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2006
Filed:
Feb. 03, 2004
Andre Gerard Bubendorf, Uffheim, FR;
Michael Hennig, Weil am Rhein, DE;
Pirmin Hidber, Basel, CH;
Goesta Rimmler, Bad Krozingen, DE;
Franziska Rohrer, Riehen, CH;
Andre Gerard Bubendorf, Uffheim, FR;
Michael Hennig, Weil am Rhein, DE;
Pirmin Hidber, Basel, CH;
Goesta Rimmler, Bad Krozingen, DE;
Franziska Rohrer, Riehen, CH;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The invention is concerned with a novel polymorph of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. This polymorph exhibits superior properties compared to the previously known forms of [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride. The [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride is an inhibitor of tyrosine kinase enzymes, and are useful in the treatment of cancer. Also disclosed are methods of making and using the novel polymorph, as well as pharmaceutical compositions containing the novel polymorph.