The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2006
Filed:
Jun. 29, 1999
Peter Francis Leadlay, Cambridge, GB;
James Staunton, Cambridge, GB;
Jesus Cortes, Cambridge, GB;
Hamish Alastair Irvine Mcarthur, Mystic, CT (US);
Peter Francis Leadlay, Cambridge, GB;
James Staunton, Cambridge, GB;
Jesus Cortes, Cambridge, GB;
Hamish Alastair Irvine McArthur, Mystic, CT (US);
Biotica Technology Limited, Cambridge, GB;
Abstract
A polyketide synthase ('PKS') of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further ketide unit which may undergo processing (e.g. reduction). We have found that the Ksq domain possessed by some PKS's has decarboxylating activity, e.g. generating (substituted) acyl from (substituted) malonyl. The CLF domain of type II PKS's has similar activity. By inserting loading modules including such domains into PKS's not normally possessing them it is possible to control the starter units used.