The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2006
Filed:
Aug. 15, 1996
Paul D. Ponath, Boston, MA (US);
Douglas J. Ringler, Revere, MA (US);
S. Tarran Jones, Radlett, GB;
Walter Newman, Boston, MA (US);
José Saldanha, Enfield, GB;
Mary M. Bendig, London, GB;
Paul D. Ponath, Boston, MA (US);
Douglas J. Ringler, Revere, MA (US);
S. Tarran Jones, Radlett, GB;
Walter Newman, Boston, MA (US);
José Saldanha, Enfield, GB;
Mary M. Bendig, London, GB;
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present invention relates to humanized immunoglobulins having binding specificity for α4β7 integrin, comprising an antigen binding region of nonhuman origin (e.g., rodent) and at least a portion of an immunoglobulin of human origin (e.g., a human framework region, a human constant region). In one embodiment, the humanized immunoglobulin can compete with murine Act-1 for binding to human α4β7 integrin. In a preferred embodiment, the antigen binding region of the humanized immunoglobulin comprises each of the complementarity determining regions of the light and heavy chains of the murine Act-1 antibody.